This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison. http://genetics564.weebly.com/
Protein Homology
What is protein homology?
Protein
homology is generally inferred from protein superfamilies .Protein
homologs can be identified by their sequence, structure, or mechanistic
similarity. Like DNA homology, protein homology denotes that the pair of
homologous organisms are descended from a common ancestor. In other
words, the two proteins are descendants of a protein in another
organism.
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PTPN2 Protein Homology
Chimpanzee
(Pan troglodytes) Protein name: PTPN2 Accession #: XM_003953237.1 Identity: 99% |
Cow
(Bos taurus) Protein Name: PTPN2 Accession #: NM_001035431.2 Identity: 98% |
Mouse
(Mus Musculus) Protein name: PTPN2 Accession #: NM_001127177.1 Identity: 82% |
Chicken
(Gallus gallus) Protein name: PTPN2 Accession #: NM_001199387.1 Identity: 78% |
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Frog
(Xenopus tropicalis) Protein name: PTPN2 Accession # NW_004668239.1 Identity: 69% Fruit Fly
(Drosophila melanogaster) Protein name: Ptp61F Accession #: NM_057339.5 Identity: 50% |
Zebrafish
(Danio rerio) Protein name: ptpn2b Accession #: NM_212654.1 Identity: 64% |
Analysis
Protein homology among different organisms is extremely beneficial for exploring your protein's function in a non-human host. Many model organisms are easier to manipulate and survey than human models. Therefore, It is often better to use a different organism to experiment with a particular human protein. Protein identity between organisms is also important to keep in mind when experimenting in different organisms, because results will not always be conclusive unless there is 100% identity.
With PTPN2 I found it beneficial to use the Drosophila protein homolog, Ptp61F, in my specific aims because of its easy manipulation and relation to the human protein. However, it might have been useful to investigate other model organisms like the mouse and the zebrafish because of its closer identity.
With PTPN2 I found it beneficial to use the Drosophila protein homolog, Ptp61F, in my specific aims because of its easy manipulation and relation to the human protein. However, it might have been useful to investigate other model organisms like the mouse and the zebrafish because of its closer identity.