This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison. http://genetics564.weebly.com/
Protein Interactions
What are protein interactions?
Protein interactions are simply other proteins or molecules that your specific protein interacts with. The STRING database allows you to visualize the most common interactions with your protein and other proteins using past experimental data. These protein interactions are determined from genomic context, high-throughput experiments, conserved coexpression, and previous knowledge.
Different colored lines in the network denote different relationships between the proteins. Pink denotes interactions from experiments, blue is from databases, and green is from textmining.
Different colored lines in the network denote different relationships between the proteins. Pink denotes interactions from experiments, blue is from databases, and green is from textmining.
STRING Database for PTPN2
Analysis
The STRING interaction networks allowed me to identify protein interactions based on their gene ontology terms. I was able to use the STRING network to further investigate PTPN2's role in glucose metabolism because of the glucose metabolism proteins found in both the drosophila and human network. (Note: As a reminder, Ptp61F is the drosophila homolog of PTPN2)
References
1. [STRING] http://string-db.org/